I can confirm I had something similar about a year ago; I *think* I
sorted it out by getting rid of all .gnome* directories under my home
directory (*think* being the operative word...).

2006/2/13, david aubril <david.aubril@ac-nantes.fr>:
>     Hello everybody.
>     Me again.
>     I finally got gnome to work ( netbsd 3.0, gnome 2.12 form pkgsrc
> 2005Q4, built with xorg ). I'm pretty happy with that. But there's
> something really weird happening: when I am logged in, gnome sometimes
> goes crazy: it says ok to everything I do, as if I was pressing the
> "enter" button all the time ( it does it in the shell, for the graphical
> applications, etc. ).
>     Hum. It kind of sounds stupid.
>     I've never seen such thing.
>     Does anybody have an idea ?
>     Best regards.
>